Dexmedetomidine Attenuates Ferroptosis-Mediated Renal Ischemia/Reperfusion Injury and Inflammation by Inhibiting ACSL4 via α2-AR

• Main Authors: Wen-hui Tao (Author), Xi-sheng Shan (Author), Jia-xin Zhang (Author), Hua-yue Liu (Author), Bi-ying Wang (Author), Xiang Wei (Author), Mian Zhang (Author), Ke Peng (Author), Jun Ding (Author), Shang-xian Xu (Author), Lin-gui Li (Author), Jun-kai Hu (Author), Xiao-wen Meng (Author), Fu-hai Ji (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ischemia-reperfusion (I/R) injury is a serious clinical pathology associated with acute kidney injury (AKI). Ferroptosis is non-apoptotic cell death that is known to contribute to renal I/R injury. Dexmedetomidine (Dex) has been shown to exert anti-inflammatory and organ protective effects. This stu...