Methods of acute biological assays in guinea-pigs for the study of toxicity and innocuity of drugs and chemicals

• Main Authors: Gui Mi Ko (Author), Adela Rosenkranz (Author), Clélia Rejane Antonio Bertoncini (Author), Neide Hyppolito Jurkiewicz (Author), Mirian Ghiraldini Franco (Author), Aron Jurkiewicz (Author)
• Format: Book
• Published: Universidade de São Paulo, 2010-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, 602 samples were tested by the following assays performed at the animal facilities (Cedeme) of the Federal University of São Paulo (UNIFESP): 385 for dermal irritability, 90 for ocular irritability (discontinued in 1995), 31 for systemic toxicity by injection, 26 for oral acute toxici...