Effects of metformin on Sonic hedgehog subgroup medulloblastoma progression: In vitro and in vivo studies

• Main Authors: Huangyi Fang (Author), Lingfei Wang (Author), Lisheng Yu (Author), Fang Shen (Author), Zelin Yang (Author), Yue Yang (Author), Shize Li (Author), Haipeng Dai (Author), Feng Tan (Author), Jian Lin (Author), Hansong Sheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metformin is a first-line drug for type 2 diabetes, and its anticancer effects have also been widely studied in recent years. The Sonic hedgehog (Shh) signaling pathway is involved in the initiation and progression of medulloblastoma. In order to develop a new treatment strategy for medulloblastoma...