Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State

• Main Authors: Tom E. Forshaw (Author), Julie A. Reisz (Author), Kimberly J. Nelson (Author), Rajesh Gumpena (Author), J. Reed Lawson (Author), Thomas J. Jönsson (Author), Hanzhi Wu (Author), Jill E. Clodfelter (Author), Lynnette C. Johnson (Author), Cristina M. Furdui (Author), W. Todd Lowther (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human peroxiredoxins (Prx) are a family of antioxidant enzymes involved in a myriad of cellular functions and diseases. During the reaction with peroxides (e.g., H₂O₂), the typical 2-Cys Prxs change oligomeric structure between higher order (do)decamers...