P53-MDM2 PATHWAY: EVIDENCES FOR A NEW TARGETED THERAPEUTIC APPROACH IN B-ACUTE LYMPHOBLASTIC LEUKEMIA

• Main Authors: Stefania Trino (Author), Luciana De Luca (Author), Ilaria Laurenzana (Author), Antonella Caivano (Author), Luigi Del Vecchio (Author), Giovanni Martinelli (Author), Pellegrino Musto (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The tumor suppressor p53 is a canonical regulator of different biological functions, like apoptosis, cell cycle arrest, DNA repair and genomic stability. This gene is frequently altered in human tumors generally by point mutations or deletions. Conversely, in acute lymphoblastic leukemia (ALL) genom...