Tangeretin prevents prostate cancer cell proliferation and induces apoptosis via activation of Notch signalling and regulating the androgen receptor (AR) pathway and the phosphoinositide 3-kinase (PI3k)/Akt/mTOR pathways

• Autori principali: Jin-Jin Guo (Autore), Ying-Jie Li (Autore), Lu-Lu Xin (Autore)
• Natura: Libro
• Pubblicazione: Bangladesh Pharmacological Society, 2015-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Despite advances in conventional therapies, treatment of prostate cancer is still a challenge. The study aims to assess the possible anti-cancer effects of tangeretin, a dietary flavonoid on human prostate cancer cells (DU145, PC3, LNCaP). Tangeretin (25, 50 and 100 µM) significantly inhibited cance...