Dual inhibition of EGFR and IL-6-STAT3 signalling by miR-146b: a potential targeted therapy for epithelial ovarian cancer

• Main Authors: Meina Yan (Author), Mutian Han (Author), Xinxin Yang (Author), Rong Shen (Author), Hui Wang (Author), Lubin Zhang (Author), Sheng Xia (Author), Peifang Yang (Author), Guanghua Zhai (Author), Qixiang Shao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epidermal growth factor receptor (EGFR) signalling and the interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) are aberrantly activated in ovarian cancer. However, inhibition of EGFR signalling in ovarian cancer patients resulted in a disappointing clinical benefit. In th...