Profiling Docetaxel in Plasma and Urine Samples from a Pediatric Cancer Patient Using Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction Combined with LC-MS/MS

• Main Authors: Olga Maliszewska (Author), Anna Roszkowska (Author), Marcin Lipiński (Author), Natalia Treder (Author), Ilona Olędzka (Author), Piotr Kowalski (Author), Tomasz Bączek (Author), Ewa Bień (Author), Małgorzata Anna Krawczyk (Author), Alina Plenis (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In recent years, therapeutic drug monitoring (TDM) has been applied in docetaxel (DOC)-based anticancer therapy to precisely control various pharmacokinetic parameters, including the concentration of DOC in biofluids (e.g., plasma or urine), its clearance, and its area under the curve (AUC). The abi...