Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge.

• Autori principali: Cecilia Perez Brandan (Autore), Angel M Padilla (Autore), Dan Xu (Autore), Rick L Tarleton (Autore), Miguel A Basombrio (Autore)
• Natura: Libro
• Pubblicazione: Public Library of Science (PLoS), 2011-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Trypanosoma cruzi is a protozoan parasite that causes severe disease in millions of habitants of developing countries. Currently there is no vaccine to prevent this disease and the available drugs have the consequences of side effects. Live vaccines are likely to be more effective in inducing protec...