Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.

• Main Authors: Suélen Fernandes Silva (Author), Angélica Hollunder Klippel (Author), Priscila Zonzini Ramos (Author), André da Silva Santiago (Author), Sandro Roberto Valentini (Author), Mario Henrique Bengtson (Author), Katlin Brauer Massirer (Author), Elizabeth Bilsland (Author), Rafael Miguez Couñago (Author), Cleslei Fernando Zanelli (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Deoxyhypusine synthase (DHS) catalyzes the first step of the post-translational modification of eukaryotic translation factor 5A (eIF5A), which is the only known protein containing the amino acid hypusine. Both proteins are essential for eukaryotic cell viability, and DHS has been suggested as a goo...