Glucose 6‐P dehydrogenase delays the onset of frailty by protecting against muscle damage

• Main Authors: Coralie Arc‐Chagnaud (Author), Andrea Salvador‐Pascual (Author), Esther Garcia‐Dominguez (Author), Gloria Olaso‐Gonzalez (Author), Angela G. Correas (Author), Eva Serna (Author), Thomas Brioche (Author), Angele Chopard (Author), Pablo J. Fernandez‐Marcos (Author), Manuel Serrano (Author), Antonio L. Serrano (Author), Pura Muñoz‐Cánoves (Author), Vicente Sebastiá (Author), Jose Viña (Author), Mari Carmen Gomez‐Cabrera (Author)
• Format: Book
• Published: Wiley, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Frailty is a major age‐associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine dinucleotide phosphate (NADPH) that is highly dependent on glucose 6‐P d...