Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

• Main Authors: Adcock Ian M (Author), Ito Misako (Author), Jalonen Ulla (Author), Ito Kazuhiro (Author), Ilmarinen-Salo Pinja (Author), Janka-Junttila Mirkka (Author), Kankaanranta Hannu (Author), Moilanen Eeva (Author), Zhang Xianzhi (Author)
• Format: Book
• Published: BMC, 2010-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Granulocytes are important in the pathogenesis of several inflammatory diseases. Apoptosis is pivotal in the resolution of inflammation. Apoptosis in malignant cells is induced by histone deacetylase (HDAC) inhibitors, whereas HDAC i...