Anti-neuropathic pain activity of Ajugarin-I via activation of Nrf2 signaling and inhibition of TRPV1/TRPM8 nociceptors in STZ-induced diabetic neuropathy

This study aimed to investigate the anti-neuropathic pain activity and its underlying molecular mechanism of Ajugarin-I (Aju-I) in a rat model of diabetic neuropathic pain. The rats were given a single injection of 60 mg/kg of streptozotocin (STZ) intraperitoneally (i.p.) to induce diabetic neuropat...

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Main Authors: Adnan Khan (Author), Feng Wang (Author), Bushra Shal (Author), Ashraf Ullah Khan (Author), Syeda Saniya Zahra (Author), Ihsan ul Haq (Author), Salman Khan (Author), Kannan RR Rengasamy (Author)
Format: Book
Published: Elsevier, 2022-09-01T00:00:00Z.
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