Application of physiologically-based pharmacokinetic/pharmacodynamic models to evaluate the interaction between nifedipine and apatinib

• Main Authors: Hongrui Liu (Author), Yiqun Yu (Author), Lu Liu (Author), Chunyan Wang (Author), Nan Guo (Author), Xiaojuan Wang (Author), Xiaoqiang Xiang (Author), Bing Han (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: It has been found that the co-administration of nifedipine with apatinib could cause exposure changes of nifedipine in vivo. But, whether this pharmacokinetic drug-drug interaction (DDI) between nifedipine and apatinib could enhance the antihypertensive effect of nifedipine, causing sever chang...