Uncovering incontinentia pigmenti: From DNA sequence to pathophysiology

• Main Authors: Kang Nien How (Author), Hazel Jing Yi Leong (Author), Zacharias Aloysius Dwi Pramono (Author), Kin Fon Leong (Author), Zee Wei Lai (Author), Wei Hsum Yap (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Incontinentia pigmenti (IP) is an X-linked dominant genodermatosis. The disease is known to be caused by recurrent deletion of exons 4-10 of the Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma (IKBKG) gene located at the Xq28 chromosomal region, which encodes for NEMO/IKKgamma, a...