Interleukin-6 and interleukin-6 receptor secretion by chronic lymphatic leukaemia and normal B lymphocytes: effect of PMA and PWM

• Main Authors: I. Drucker (Author), A. Klajman (Author), M. Revel (Author), Y. Manor (Author), S. Ben-Efraim (Author), D. Novick (Author)
• Format: Book
• Published: Hindawi Limited, 1997-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6R) were detected in supernatants of cultures of B chronic lymphatic leukaemia (CLL) lymphocytes. Phorbol-12-myristate 13 acetate (PMA) caused a decrease in the levels of IL-6 in 14 out of 16 cultures and an increase in levels of sIL6R in...