Recent Advances in the Discovery of SIRT1/2 Inhibitors via Computational Methods: A Perspective

• Main Authors: Naomi Scarano (Author), Chiara Brullo (Author), Francesca Musumeci (Author), Enrico Millo (Author), Santina Bruzzone (Author), Silvia Schenone (Author), Elena Cichero (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sirtuins (SIRTs) are classified as class III histone deacetylases (HDACs), a family of enzymes that catalyze the removal of acetyl groups from the ε-N-acetyl lysine residues of histone proteins, thus counteracting the activity performed by histone acetyltransferares (HATs). Based on their involvemen...