Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles during Dissolution

• Main Authors: Miguel O. Jara (Author), Zachary N. Warnken (Author), Sawittree Sahakijpijarn (Author), Rishi Thakkar (Author), Vineet R. Kulkarni (Author), Dale J. Christensen (Author), John J. Koleng (Author), Robert O. Williams (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage. Unfortunately, niclosamide is a poorly water soluble molecule, with reduced oral b...