Conservation and immunogenicity of novel antigens in diverse isolates of enterotoxigenic Escherichia coli.

• Main Authors: Qingwei Luo (Author), Firdausi Qadri (Author), Rita Kansal (Author), David A Rasko (Author), Alaullah Sheikh (Author), James M Fleckenstein (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Enterotoxigenic Escherichia coli (ETEC) are common causes of diarrheal morbidity and mortality in developing countries for which there is currently no vaccine. Heterogeneity in classical ETEC antigens known as colonization factors (CFs) and poor efficacy of toxoid-based approaches to date...