A Putative Mechanism of Age-Related Synaptic Dysfunction Based on the Impact of IGF-1 Receptor Signaling on Synaptic CaMKIIα Phosphorylation

Insulin-like growth factor 1 receptor (IGF-1R) signaling regulates the activity and phosphorylation of downstream kinases linked to inflammation, neurodevelopment, aging and synaptic function. In addition to the control of Ca2+ currents, IGF-1R signaling modulates the activity of calcium-calmodulin-...

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Main Authors: Olalekan M. Ogundele (Author), Joaquin Pardo (Author), Joseph Francis (Author), Rodolfo G. Goya (Author), Charles C. Lee (Author)
Format: Book
Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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