Inhibition of inflammatory liver injury by the HMGB1-A box through HMGB1/TLR-4/NF-κB signaling in an acute liver failure mouse model

• Main Authors: Lidan Luo (Author), Shuai Wang (Author), Bohao Chen (Author), Mei Zhong (Author), Ruili Du (Author), ChunShan Wei (Author), Furong Huang (Author), Xinhui Kou (Author), Yufeng Xing (Author), Guangdong Tong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We aimed to investigate the preventive effect of high mobility group box 1 (HMGB1)-A box and the mechanism by which it alleviates inflammatory injury in acute liver failure (ALF) by inhibiting the extracellular release of HMGB1. BALB/c mice were intraperitoneally (i.p.) administered LPS/D-GalN to es...