Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions

• Главные авторы: Donald J. Clancy (Автор), Gulenay Guner (Автор), Sayantan Chattoraj (Автор), Helen Yao (Автор), M. Connor Faith (Автор), Zahra Salahshoor (Автор), Kailey N. Martin (Автор), Ecevit Bilgili (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2024-03-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

This study aimed to develop a practical semi-mechanistic modeling framework to predict particle size evolution during wet bead milling of pharmaceutical nanosuspensions over a wide range of process conditions and milling scales. The model incorporates process parameters, formulation parameters, and...