Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions

• Principais autores: Donald J. Clancy (Autor), Gulenay Guner (Autor), Sayantan Chattoraj (Autor), Helen Yao (Autor), M. Connor Faith (Autor), Zahra Salahshoor (Autor), Kailey N. Martin (Autor), Ecevit Bilgili (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2024-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

This study aimed to develop a practical semi-mechanistic modeling framework to predict particle size evolution during wet bead milling of pharmaceutical nanosuspensions over a wide range of process conditions and milling scales. The model incorporates process parameters, formulation parameters, and...