Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions

• Main Authors: Donald J. Clancy (Author), Gulenay Guner (Author), Sayantan Chattoraj (Author), Helen Yao (Author), M. Connor Faith (Author), Zahra Salahshoor (Author), Kailey N. Martin (Author), Ecevit Bilgili (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to develop a practical semi-mechanistic modeling framework to predict particle size evolution during wet bead milling of pharmaceutical nanosuspensions over a wide range of process conditions and milling scales. The model incorporates process parameters, formulation parameters, and...