Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation

• Main Authors: Wagdy M. Eldehna (Author), Mahmoud F. Abo-Ashour (Author), Hany S. Ibrahim (Author), Ghada H. Al-Ansary (Author), Hazem A. Ghabbour (Author), Mahmoud M. Elaasser (Author), Hanaa Y. A. Ahmed (Author), Nesreen A. Safwat (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

On account of their significance as apoptosis inducing agents, merging indole and 3-hydrazinoindolin-2-one scaffolds is a logic tactic for designing pro-apoptotic agents. Consequently, 27 hybrids (6a-r, 9a-f and 11a-c) were synthesised and evaluated for their cytotoxicity against MCF-7, HepG-2 and H...