Physiologically based absorption modeling to predict the bioequivalence of two apixaban formulations

• Hauptverfasser: Ting Luo (Verfasst von), Lu Wang (Verfasst von), Zourong Ruan (Verfasst von), Honggang Lou (Verfasst von), Dandan Yang (Verfasst von), Zhiyang Wang (Verfasst von), Pengfei Zhao (Verfasst von), Bo Jiang (Verfasst von)
• Format: Buch
• Veröffentlicht: Wiley, 2024-05-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract The equivalence of absorption rates and extents between generic drugs and their reference formulations is crucial for ensuring therapeutic comparability. Bioequivalence (BE) studies are widely utilized and play a pivotal role in substantiating the approval and promotional efforts for generi...