Extracellular Guanosine 5'-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine

• Main Authors: Tiziana Pietrangelo (Author), Ester S. Di Filippo (Author), Marcello Locatelli (Author), Francesco Piacenza (Author), Marco Farina (Author), Eleonora Pavoni (Author), Andrea Di Donato (Author), Denise Innosa (Author), Mauro Provinciali (Author), Stefania Fulle (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The extracellular guanosine 5'-triphosphate, GTP, has been demonstrated to be an enhancer of myogenic cell differentiation in a murine cell line, not yet in human muscle cells. Our hypothesis was that GTP could influence also human skeletal muscle regeneration, specifically in the first phases....