The Complexity of Bariatric Patient's Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass

• Main Authors: Daniel Porat (Author), Oleg Dukhno (Author), Sandra Cvijić (Author), Arik Dahan (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2023-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Postbariatric altered gastrointestinal (GI) anatomy/physiology may significantly harm oral drug absorption and overall bioavailability. In this work, sildenafil, the first phosphodiesterase-5 (PDE5) inhibitor, was investigated for impaired postbariatric solubility/dissolution and absorption; this re...