Repurposing Heparin as Antimalarial: Evaluation of Multiple Modifications Toward In Vivo Application

• Principais autores: Elena Lantero (Autor), Carlos Raúl Aláez-Versón (Autor), Pilar Romero (Autor), Teresa Sierra (Autor), Xavier Fernàndez-Busquets (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2020-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Heparin is a promising antimalarial drug due to its activity in inhibiting <i>Plasmodium</i> invasion of red blood cells and to the lack of resistance evolution by the parasite against it, but its potent anticoagulant activity is preventing the advance of heparin along the clinical pipel...