Repurposing Heparin as Antimalarial: Evaluation of Multiple Modifications Toward In Vivo Application

• Glavni autori: Elena Lantero (Autor), Carlos Raúl Aláez-Versón (Autor), Pilar Romero (Autor), Teresa Sierra (Autor), Xavier Fernàndez-Busquets (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2020-08-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Heparin is a promising antimalarial drug due to its activity in inhibiting <i>Plasmodium</i> invasion of red blood cells and to the lack of resistance evolution by the parasite against it, but its potent anticoagulant activity is preventing the advance of heparin along the clinical pipel...