Interfering B cell receptor signaling via SHP-1/p-Lyn axis shows therapeutic potential in diffuse large B-cell lymphoma

• Main Authors: Ji-Lin Chen (Author), Pei-Yi Chu (Author), Chun-Teng Huang (Author), Tzu-Ting Huang (Author), Wan-Lun Wang (Author), Yu-Hsuan Lee (Author), Yuan-Ya Chang (Author), Ming-Shen Dai (Author), Chung-Wai Shiau (Author), Chun-Yu Liu (Author)
• Format: Book
• Published: BMC, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Diffuse large B cell lymphoma (DLBCL) is an aggressive and molecularly heterogeneous non-Hodgkin's lymphoma. The B cell receptor (BCR) signaling pathway in DLBCL emerges as a new drug target. Protein phosphatase SHP-1 negatively regulates several oncogenic tyrosine kinases a...