Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.

• Main Authors: Cho Yeow Koh (Author), Jessica E Kim (Author), Allan B Wetzel (Author), Will J de van der Schueren (Author), Sayaka Shibata (Author), Ranae M Ranade (Author), Jiyun Liu (Author), Zhongsheng Zhang (Author), J Robert Gillespie (Author), Frederick S Buckner (Author), Christophe L M J Verlinde (Author), Erkang Fan (Author), Wim G J Hol (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methionyl-tRNA synthetase of Trypanosoma brucei (TbMetRS) is an important target in the development of new antitrypanosomal drugs. The enzyme is essential, highly flexible and displaying a large degree of changes in protein domains and binding pockets in the presence of substrate, product and inhibi...