Intranasal Administration of <i>N</i>-acetyl-<span style="font-variant: small-caps">L</span>-cysteine Combined with Cell-Penetrating Peptide-Modified Polymer Nanomicelles as a Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis

• Main Authors: Takumi Kurano (Author), Takanori Kanazawa (Author), Shingo Iioka (Author), Hiromu Kondo (Author), Yasuhiro Kosuge (Author), Toyofumi Suzuki (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intranasal administration is a promising route for direct drug delivery to the brain; its combination with nanocarriers enhances delivery. We have previously shown that intranasal administration combined with PEG-PCL-Tat (a nanocarrier) efficiently delivers drugs to the brain and exhibits excellent...