Pioglitazone Protects Against Renal Ischemia-Reperfusion Injury via the AMP-Activated Protein Kinase-Regulated Autophagy Pathway

• Main Authors: Wenlin Chen (Author), Xiaoqing Xi (Author), Shuangyang Zhang (Author), Cong Zou (Author), Renrui Kuang (Author), Zhenfeng Ye (Author), Yawei Huang (Author), Honglin Hu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Renal ischemia-reperfusion injury (IRI) is a major cause of acute renal failure. Our previous studies have shown that pioglitazone, a peroxisome proliferators-activated receptor (PPAR)-γ agonist used in type 2 diabetes, protects against renal IRI; however, the molecular mechanism underlying the reno...