Anti-miR-223-5p Ameliorates Ischemic Damage and Improves Neurological Function by Preventing NCKX2 Downregulation after Ischemia in Rats

• Main Authors: Ornella Cuomo (Author), Pasquale Cepparulo (Author), Serenella Anzilotti (Author), Angelo Serani (Author), Rossana Sirabella (Author), Paola Brancaccio (Author), Natascia Guida (Author), Valeria Valsecchi (Author), Antonio Vinciguerra (Author), Pasquale Molinaro (Author), Luigi Formisano (Author), Lucio Annunziato (Author), Giuseppe Pignataro, MD PhD (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It has been demonstrated that the K+-dependent Na+/Ca2+ exchanger, NCKX2, is a new promising stroke neuroprotective target. However, because no pharmacological activator of NCKX2 is still available, microRNA (miRNA) may represent an alternative method to modulate NCKX2 expression. In particular, by...