Water Uptake by Evaporating pMDI Aerosol Prior to Inhalation Affects Both Regional and Total Deposition in the Respiratory System

• Autores principales: Victoria Legh-Land (Autor), Allen E. Haddrell (Autor), David Lewis (Autor), Darragh Murnane (Autor), Jonathan P. Reid (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2021-06-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

As pulmonary drug deposition is a function of aerosol particle size distribution, it is critical that the dynamics of particle formation and maturation in pMDI sprays in the interim between generation and inhalation are fully understood. This paper presents an approach to measure the evaporative and...