Targeted Endoradiotherapy with Lu₂O₃-iPSMA/-iFAP Nanoparticles Activated by Neutron Irradiation: Preclinical Evaluation and First Patient Image

• Main Authors: Myrna Luna-Gutiérrez (Author), Blanca Ocampo-García (Author), Nallely Jiménez-Mancilla (Author), Alejandra Ancira-Cortez (Author), Diana Trujillo-Benítez (Author), Tania Hernández-Jiménez (Author), Gerardo Ramírez-Nava (Author), Rodrigo Hernández-Ramírez (Author), Clara Santos-Cuevas (Author), Guillermina Ferro-Flores (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prostate-specific membrane antigen (PSMA) is expressed in a variety of cancer cells, while the fibroblast activation protein (FAP) is expressed in the microenvironment of tumors. Previously, we reported the ability of iPSMA and iFAP ligands to specifically target PSMA and FAP proteins, as well as th...