Cover Image

Targeted Endoradiotherapy with Lu<sub>2</sub>O<sub>3</sub>-iPSMA/-iFAP Nanoparticles Activated by Neutron Irradiation: Preclinical Evaluation and First Patient Image

Prostate-specific membrane antigen (PSMA) is expressed in a variety of cancer cells, while the fibroblast activation protein (FAP) is expressed in the microenvironment of tumors. Previously, we reported the ability of iPSMA and iFAP ligands to specifically target PSMA and FAP proteins, as well as th...

Full description

Saved in:

Bibliographic Details
Main Authors:	Myrna Luna-Gutiérrez (Author), Blanca Ocampo-García (Author), Nallely Jiménez-Mancilla (Author), Alejandra Ancira-Cortez (Author), Diana Trujillo-Benítez (Author), Tania Hernández-Jiménez (Author), Gerardo Ramírez-Nava (Author), Rodrigo Hernández-Ramírez (Author), Clara Santos-Cuevas (Author), Guillermina Ferro-Flores (Author)
Format:	Book
Published:	MDPI AG, 2022-03-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Improving Overall Survival and Quality of Life in Patients with Prostate Cancer and Neuroendocrine Tumors Using <sup>177</sup>Lu-iPSMA and <sup>177</sup>Lu-DOTATOC: Experience after 905 Treatment Doses
by: Myrna Luna-Gutiérrez, et al.
Published: (2023)

Preclinical comparison of [177Lu]Lu-rhPSMA-10.1 and [177Lu]Lu-rhPSMA-10.2 for endoradiotherapy of prostate cancer: biodistribution and dosimetry studies
by: Alexander Wurzer, et al.
Published: (2024)

Theranostic Potential of the iPSMA-Bombesin Radioligand in Patients with Metastatic Prostate Cancer: A Pilot Study
by: Sofía González-Rueda, et al.
Published: (2024)

Association of <i>bla</i><sub>VIM-2</sub>, <i>bla</i><sub>PDC-35</sub>, <i>bla</i><sub>OXA-10,</sub> <i>bla</i><sub>OXA-488</sub> and <i>bla</i><sub>VEB-9</sub> β-Lactamase Genes with Resistance to Ceftazidime-Avibactam and Ceftolozane-Tazobactam in Multidrug-Resistant <i>Pseudomonas aeruginosa</i>
by: Mazen A. Sid Ahmed, et al.
Published: (2022)

Therapeutic Efficacy of <sup>177</sup>Lu-Labeled A20FMDV2 Peptides Targeting α<sub>ν</sub>β<sub>6</sub>
by: Truc Thao Huynh, et al.
Published: (2022)

Radiosynthesis of Stable <sup>198</sup>Au-Nanoparticles by Neutron Activation of α<sub>v</sub>β<sub>3</sub>-Specific AuNPs for Therapy of Tumor Angiogenesis
by: Güllü Davarci, et al.
Published: (2023)

<i>Pseudomonas aeruginosa</i> Coharboring <i>Bla</i><sub>KPC-2</sub> and <i>Bla</i><sub>VIM-2</sub> Carbapenemase Genes
by: Tatiana Pacheco, et al.
Published: (2019)

Computational Design of Inhibitors Targeting the Catalytic β Subunit of <i>Escherichia coli</i> F<sub>O</sub>F<sub>1</sub>-ATP Synthase
by: Luis Pablo Avila-Barrientos, et al.
Published: (2022)

The Short Lipopeptides (C<sub>10</sub>)<sub>2</sub>-KKKK-NH<sub>2</sub> and (C<sub>12</sub>)<sub>2</sub>-KKKK-NH<sub>2</sub> Protect HaCaT Keratinocytes from Bacterial Damage Caused by <i>Staphylococcus aureus</i> Infection in a Co-Culture Model
by: Kirsten Reddersen, et al.
Published: (2020)

Improved quality control of [177Lu]Lu-PSMA I&T
by: Martin Kraihammer, et al.
Published: (2023)

First-In-Human Results on the Biodistribution, Pharmacokinetics, and Dosimetry of [<sup>177</sup>Lu]Lu-DOTA.SA.FAPi and [<sup>177</sup>Lu]Lu-DOTAGA.(SA.FAPi)<sub>2</sub>
by: Sanjana Ballal, et al.
Published: (2021)

The Genetic Characteristics and Carbapenem Resistance Mechanism of ST307 <i>Klebsiella pneumoniae</i> Coharbouring <i>bla</i><sub>CMY-6</sub>, <i>bla</i><sub>OXA-48</sub>, and a Truncated <i>bla</i><sub>NDM-1</sub>
by: Qiucheng Shi, et al.
Published: (2022)

[<sup>99m</sup>Tc]Tc-iFAP Radioligand for SPECT/CT Imaging of the Tumor Microenvironment: Kinetics, Radiation Dosimetry, and Imaging in Patients
by: Luis Coria-Domínguez, et al.
Published: (2022)

Potential Inhibitory Effect of <i>Apis mellifera</i>'s Venom and of Its Two Main Components-Melittin and PLA<sub>2</sub>-on <i>Escherichia coli</i> F<sub>1</sub>F<sub>0</sub>-ATPase
by: Hala Nehme, et al.
Published: (2020)

Spermidine Improves Freezing Tolerance by Regulating H<sub>2</sub>O<sub>2</sub> in <i>Brassica napus</i> L.
by: Shun Li, et al.
Published: (2024)

Development of Biocompatible Ga<sub>2</sub>(HPO<sub>4</sub>)<sub>3</sub> Nanoparticles as an Antimicrobial Agent with Improved Ga Resistance Development Profile against <i>Pseudomonas aeruginosa</i>
by: Huda Alamri, et al.
Published: (2023)

Genome-Based Analyses of Fitness Effects and Compensatory Changes Associated with Acquisition of <i>bla</i><sub>CMY</sub>-, <i>bla</i><sub>CTX-M</sub>-, and <i>bla</i><sub>OXA-48/VIM-1</sub>-Containing Plasmids in <i>Escherichia coli</i>
by: Michael Pietsch, et al.
Published: (2021)

Characterization of <i>bla</i><sub>KPC-2</sub> and <i>bla</i><sub>NDM-1</sub> Plasmids of a <i>K. pneumoniae</i> ST11 Outbreak Clone
by: Camila Maria dos Santos Boralli, et al.
Published: (2023)

<sup>64</sup>Cu-DOTHA<sub>2</sub>-PSMA, a Novel PSMA PET Radiotracer for Prostate Cancer with a Long Imaging Time Window
by: Marie-Christine Milot, et al.
Published: (2022)

Neonatal Bloodstream Infection with Ceftazidime-Avibactam-Resistant <i>bla</i><sub>KPC-2</sub>-Producing <i>Klebsiella pneumoniae</i> Carrying <i>bla</i><sub>VEB-25</sub>
by: Charalampos Zarras, et al.
Published: (2023)

Emergence of <i>bla</i><sub>NDM-5</sub> and <i>bla</i><sub>OXA-232</sub> Positive Colistin- and Carbapenem-Resistant <i>Klebsiella pneumoniae</i> in a Bulgarian Hospital
by: Rumyana Markovska, et al.
Published: (2024)

Cytosol Peroxiredoxin and Cell Surface Catalase Differentially Respond to H<sub>2</sub>O<sub>2</sub> Stress in <i>Aspergillus nidulans</i>
by: Yunfeng Yan, et al.
Published: (2023)

In Vitro Activity of New β-Lactamase Inhibitor Combinations against <i>bla</i><sub>NDM</sub>, <i>bla</i><sub>KPC</sub>, and ESBL-Producing Enterobacteriales Uropathogens
by: Lubna Razaq, et al.
Published: (2023)

Characterization of <i>bla</i><sub>NDM-5</sub>-and <i>bla</i><sub>CTX-M-199</sub>-Producing ST167 <i>Escherichia coli</i> Isolated from Shared Bikes
by: Qiyan Chen, et al.
Published: (2022)

Competition between H<sub>4</sub>PteGlu and H<sub>2</sub>PtePAS Confers <i>para</i>-Aminosalicylic Acid Resistance in <i>Mycobacterium tuberculosis</i>
by: Ji-Fang Yu, et al.
Published: (2023)

<i>Pistacia vera</i> Extract Potentiates the Effect of Melatonin on Human Melatonin MT<sub>1</sub> and MT<sub>2</sub> Receptors with Functional Selectivity
by: Nedjma Labani, et al.
Published: (2023)

Dissemination of Ceftriaxone-Resistant <i>Salmonella</i> Enteritidis Harboring Plasmids Encoding <i>bla</i><sub>CTX-M-55</sub> or <i>bla</i><sub>CTX-M-14</sub> Gene in China
by: Siyuan Yang, et al.
Published: (2024)

Synergistic Antibacterial Effects of Meropenem in Combination with Aminoglycosides against Carbapenem-Resistant <i>Escherichia coli</i> Harboring <i>bla</i><sub>NDM-1</sub> and <i>bla</i><sub>NDM-5</sub>
by: Pawarisa Terbtothakun, et al.
Published: (2021)

Enhancing Bioactive Components of <i>Euryale ferox</i> with <i>Lactobacillus curvatus</i> to Reduce H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress in Human Skin Fibroblasts
by: Yanbing Jiang, et al.
Published: (2022)

H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress Responses in <i>Eriocheir sinensis</i>: Antioxidant Defense and Immune Gene Expression Dynamics
by: Qinghong He, et al.
Published: (2024)

The Role of H<sub>2</sub>O<sub>2</sub>-Scavenging Enzymes (Ascorbate Peroxidase and Catalase) in the Tolerance of <i>Lemna minor</i> to Antibiotics: Implications for Phytoremediation
by: Marcelo Pedrosa Gomes, et al.
Published: (2022)

Interhospital Spread of <i>bla</i><sub>VIM-1</sub>- and <i>bla</i><sub>CTX-M-15</sub>-Producing <i>K. pneumoniae</i> ST15 on an IncR Plasmid in Southern Spain
by: Patricia Pérez-Palacios, et al.
Published: (2023)

ST11 Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Clone Harboring <i>bla</i><sub>NDM</sub> Replaced a <i>bla</i><sub>KPC</sub> Clone in a Tertiary Hospital in China
by: Qiaoyan Duan, et al.
Published: (2022)

Rapid Reversal of Carbapenemase-Producing <i>Pseudomonas aeruginosa</i> Epidemiology from <i>bla</i><sub>VIM</sub>- to <i>bla</i><sub>NDM</sub>-harbouring Isolates in a Greek Tertiary Care Hospital
by: Efthymia Protonotariou, et al.
Published: (2024)

Transposon-Directed Insertion-Site Sequencing Reveals Glycolysis Gene <i>gpmA</i> as Part of the H<sub>2</sub>O<sub>2</sub> Defense Mechanisms in <i>Escherichia coli</i>
by: Myriam Roth, et al.
Published: (2022)

<i>Moringa concanensis</i>-Mediated Synthesis and Characterizations of Ciprofloxacin Encapsulated into Ag/TiO<sub>2</sub>/Fe<sub>2</sub>O<sub>3</sub>/CS Nanocomposite: A Therapeutic Solution against Multidrug Resistant <i>E. coli</i> Strains of Livestock Infectious Diseases
by: Naheed Zafar, et al.
Published: (2022)

Biotransformation of ginsenosides Rb<sub>1</sub>, Rg<sub>3 </sub>and Rh<sub>2 </sub>in rat gastrointestinal tracts
by: Qian Tianxiu, et al.
Published: (2010)

Interference Expression of <i>StMSD</i> Inhibited the Deposition of Suberin and Lignin at Wounds of Potato Tubers by Reducing the Production of H<sub>2</sub>O<sub>2</sub>
by: Ying-Yue Ren, et al.
Published: (2022)

The Catalase KatA Contributes to Microaerophilic H<sub>2</sub>O<sub>2</sub> Priming to Acquire an Improved Oxidative Stress Resistance in <i>Staphylococcus aureus</i>
by: Nico Linzner, et al.
Published: (2022)

Genomic Characterization of 16S rRNA Methyltransferase-Producing <i>Enterobacterales</i> Reveals the Emergence of <i>Klebsiella pneumoniae</i> ST6260 Harboring <i>rmtF</i>, <i>rmtB</i>, <i>bla</i><sub>NDM-5</sub>, <i>bla</i><sub>OXA-232</sub> and <i>bla</i><sub>SFO-1</sub> Genes in a Cancer Hospital in Bulgaria
by: Stefana Sabtcheva, et al.
Published: (2024)