Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia

• Main Authors: Iki Sonn (Author), Fumiko Honda-Ozaki (Author), Sho Yoshimatsu (Author), Satoru Morimoto (Author), Hirotaka Watanabe (Author), Hideyuki Okano (Author)
• Format: Book
• Published: BMC, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Microglia are innate immune cells that are the only residential macrophages in the central nervous system. They play vital physiological roles in the adult brain and during development. Microglia are particularly in the spotlight because many genetic risk factors recently identif...