Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes

Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes

Y-box binding protein-1 (YB-1), involved in cancer progression and chemoradiation resistance, is overexpressed in not only cancer cells but also tumor blood vessels. In this study, we investigated the potential value of amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides (ASOs) tar...

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Main Authors: Kiyoko Setoguchi (Author), Lin Cui (Author), Nobutaka Hachisuka (Author), Sumalee Obchoei (Author), Kentaro Shinkai (Author), Fuminori Hyodo (Author), Kiyoko Kato (Author), Fumito Wada (Author), Tsuyoshi Yamamoto (Author), Mariko Harada-Shiba (Author), Satoshi Obika (Author), Kenji Nakano (Author)
Format: Book
Published: Elsevier, 2017-12-01T00:00:00Z.
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