Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes

• Hlavní autoři: Kiyoko Setoguchi (Autor), Lin Cui (Autor), Nobutaka Hachisuka (Autor), Sumalee Obchoei (Autor), Kentaro Shinkai (Autor), Fuminori Hyodo (Autor), Kiyoko Kato (Autor), Fumito Wada (Autor), Tsuyoshi Yamamoto (Autor), Mariko Harada-Shiba (Autor), Satoshi Obika (Autor), Kenji Nakano (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2017-12-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Y-box binding protein-1 (YB-1), involved in cancer progression and chemoradiation resistance, is overexpressed in not only cancer cells but also tumor blood vessels. In this study, we investigated the potential value of amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides (ASOs) tar...