Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB)

• Main Authors: Sesha Hanson-Drury (Author), Anjali P. Patni (Author), Deborah L. Lee (Author), Ammar Alghadeer (Author), Yan Ting Zhao (Author), Devon Duron Ehnes (Author), Vivian N. Vo (Author), Sydney Y. Kim (Author), Druthi Jithendra (Author), Ashish Phal (Author), Natasha I. Edman (Author), Thomas Schlichthaerle (Author), David Baker (Author), Jessica E. Young (Author), Julie Mathieu (Author), Hannele Ruohola-Baker (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Over 90% of the U.S. adult population suffers from tooth structure loss due to caries. Most of the mineralized tooth structure is composed of dentin, a material produced and mineralized by ectomesenchyme derived cells known as odontoblasts. Clinicians, scientists, and the general public share the de...