Modeling Neurological Disease by Rapid Conversion of Human Urine Cells into Functional Neurons

• Main Authors: Shu-Zhen Zhang (Author), Li-Xiang Ma (Author), Wen-Jing Qian (Author), Hong-Fu Li (Author), Zhong-Feng Wang (Author), Hong-Xia Wang (Author), Zhi-Ying Wu (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Somatic cells can be directly converted into functional neurons by ectopic expression of defined factors and/or microRNAs. Since the first report of conversion mouse embryonic fibroblasts into functional neurons, the postnatal mouse, and human fibroblasts, astroglia, hepatocytes, and pericyte-derive...