Regioselective Hydroxylation of Phloretin, a Bioactive Compound from Apples, by Human Cytochrome P450 Enzymes

• Main Authors: Ngoc Anh Nguyen (Author), Ngoc Tan Cao (Author), Thi Huong Ha Nguyen (Author), Thien-Kim Le (Author), Gun Su Cha (Author), Soo-Keun Choi (Author), Jae-Gu Pan (Author), Soo-Jin Yeom (Author), Hyung-Sik Kang (Author), Chul-Ho Yun (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phloretin, the major polyphenol compound in apples and apple products, is interesting because it shows beneficial effects on human health. It is mainly found as a form of glucoside, phlorizin. However, the metabolic pathway of phloretin in humans has not been reported. Therefore, identifying phloret...