A novel rabbit model of Duchenne muscular dystrophy generated by CRISPR/Cas9

• Main Authors: Tingting Sui (Author), Yeh Siang Lau (Author), Di Liu (Author), Tingjun Liu (Author), Li Xu (Author), Yandi Gao (Author), Liangxue Lai (Author), Zhanjun Li (Author), Renzhi Han (Author)
• Format: Book
• Published: The Company of Biologists, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disorder caused by mutations in the dystrophin gene, with an incidence of 1 in 3500 in new male births. Mdx mice are widely used as an animal model for DMD. However, these mice do not faithfully recapitulate DMD patients in many aspects...