Evaluating the effectiveness of a novel somatostatin receptor 2 antagonist, ZT-01, for hypoglycemia prevention in a rodent model of type 2 diabetes

• Main Authors: Ninoschka C. D'Souza (Author), Julian A. Aiken (Author), Emily G. Hoffman (Author), Sara C. Atherley (Author), Sabrina Champsi (Author), Nadia Aleali (Author), Dorsa Shakeri (Author), Maya El-Zahed (Author), Nicky Akbarian (Author), Mehran Nejad-Mansouri (Author), Parinaz Z. Bavani (Author), Richard L. Liggins (Author), Owen Chan (Author), Michael C. Riddell (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Elevated levels of somatostatin blunt glucagon counterregulation during hypoglycemia in type 1 diabetes (T1D) and this can be improved using somatostatin receptor 2 (SSTR2) antagonists. Hypoglycemia also occurs in late-stage type 2 diabetes (T2D), particularly when insulin therapy is ini...