Delta-Like-1 Changes the Immunomodulatory Property of OP9 Cells

• Main Authors: Lei Zhang (Author), Rui-Jie Dang (Author), Yan-Mei Yang (Author), Dian-Chao Cui (Author), Ping Li (Author), Yan-Li Ni (Author), Tong Hao (Author), Changyong Wang (Author), Xiao-Xia Jiang (Author), Nan-Zhu Fang (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As stromal cells and recently confirmed mesenchymal stem cells, OP9 cells support hematopoiesis stem cell (HSC) differentiation into the B lymphocyte lineage, yet Delta-like-1 (DL1) overexpressing OP9 (OP9DL1) cells promote the development of early T lymphocytes from HSC. However, the immunomodulato...