Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers

• Main Authors: Tingting Jiang (Author), Guan Wang (Author), Yao Liu (Author), Lu Feng (Author), Meng Wang (Author), Jie Liu (Author), Yi Chen (Author), Liang Ouyang (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tropomyosin receptor kinase A, B and C (TRKA, TRKB and TRKC), which are well-known members of the cell surface receptor tyrosine kinase (RTK) family, are encoded by the neurotrophic receptor tyrosine kinase 1, 2 and 3 (NTRK1, NTRK2 and NTRK3) genes, respectively. TRKs can regulate cell proliferation...