Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers

• المؤلفون الرئيسيون: Tingting Jiang (مؤلف), Guan Wang (مؤلف), Yao Liu (مؤلف), Lu Feng (مؤلف), Meng Wang (مؤلف), Jie Liu (مؤلف), Yi Chen (مؤلف), Liang Ouyang (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2021-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Tropomyosin receptor kinase A, B and C (TRKA, TRKB and TRKC), which are well-known members of the cell surface receptor tyrosine kinase (RTK) family, are encoded by the neurotrophic receptor tyrosine kinase 1, 2 and 3 (NTRK1, NTRK2 and NTRK3) genes, respectively. TRKs can regulate cell proliferation...