Deletion of miPEP in adipocytes protects against obesity and insulin resistance by boosting muscle metabolism

• Main Authors: Alexis Diaz-Vegas (Author), Kristen C. Cooke (Author), Harry B. Cutler (Author), Belinda Yau (Author), Stewart W.C. Masson (Author), Dylan Harney (Author), Oliver K. Fuller (Author), Meg Potter (Author), Søren Madsen (Author), Niamh R. Craw (Author), Yiju Zhang (Author), Cesar L. Moreno (Author), Melkam A. Kebede (Author), G. Gregory Neely (Author), Jacqueline Stöckli (Author), James G. Burchfield (Author), David E. James (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondria facilitate thousands of biochemical reactions, covering a broad spectrum of anabolic and catabolic processes. Here we demonstrate that the adipocyte mitochondrial proteome is markedly altered across multiple models of insulin resistance and reveal a consistent decrease in the level of t...