The Growing Spectrum of DADA2 Manifestations-Diagnostic and Therapeutic Challenges Revisited

• Main Authors: Carolin Escherich (Author), Benedikt Bötticher (Author), Stefani Harmsen (Author), Marc Hömberg (Author), Jörg Schaper (Author), Myriam Ricarda Lorenz (Author), Klaus Schwarz (Author), Arndt Borkhardt (Author), Prasad Thomas Oommen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Deficiency of Adenosine Deaminase Type 2 (DADA2) is a rare autosomal recessive inherited disorder with a variable phenotype including generalized or cerebral vasculitis and bone marrow failure. It is caused by variations in the adenosine deaminase 2 gene (ADA2), which leads to decreased adenosine de...