Targeting ANGPTL3 by GalNAc-conjugated siRNA ANGsiR10 lowers blood lipids with long-lasting and potent efficacy in mice and monkeys

• Main Authors: Jue Wang (Author), Wen Zheng (Author), Shuquan Zheng (Author), Ye Yuan (Author), Wei Wen (Author), Weiyi Cui (Author), Lifang Xue (Author), Xueting Sun (Author), Haibao Shang (Author), Hongyan Zhang (Author), Rui-Ping Xiao (Author), Shan Gao (Author), Xiuqin Zhang (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiopoietin-like protein 3 (ANGPTL3) is an important regulator of lipoproteins by inhibiting both lipoprotein and endothelial lipases. It has been intensively investigated as a drug target for the treatment of dyslipidemia. In the present study, a modified small interfering RNA (siRNA) conjugated w...