Targeting ANGPTL3 by GalNAc-conjugated siRNA ANGsiR10 lowers blood lipids with long-lasting and potent efficacy in mice and monkeys

• मुख्य लेखकों: Jue Wang (लेखक), Wen Zheng (लेखक), Shuquan Zheng (लेखक), Ye Yuan (लेखक), Wei Wen (लेखक), Weiyi Cui (लेखक), Lifang Xue (लेखक), Xueting Sun (लेखक), Haibao Shang (लेखक), Hongyan Zhang (लेखक), Rui-Ping Xiao (लेखक), Shan Gao (लेखक), Xiuqin Zhang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Angiopoietin-like protein 3 (ANGPTL3) is an important regulator of lipoproteins by inhibiting both lipoprotein and endothelial lipases. It has been intensively investigated as a drug target for the treatment of dyslipidemia. In the present study, a modified small interfering RNA (siRNA) conjugated w...