Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase

The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters were investigated for the inhibition of acetylcholinesterase. Two of the tacrine...

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Bibliographic Details
Main Authors: Tereza Cristina Santos Evangelista (Author), Óscar López (Author), Sabrina Baptista Ferreira (Author), José G. Fernández-Bolaños (Author), Magne O. Sydnes (Author), Emil Lindbäck (Author)
Format: Book
Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
Copy 1 Available