Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase

• 主要な著者: Tereza Cristina Santos Evangelista (著者), Óscar López (著者), Sabrina Baptista Ferreira (著者), José G. Fernández-Bolaños (著者), Magne O. Sydnes (著者), Emil Lindbäck (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters were investigated for the inhibition of acetylcholinesterase. Two of the tacrine...