Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase

• Main Authors: Tereza Cristina Santos Evangelista (Author), Óscar López (Author), Sabrina Baptista Ferreira (Author), José G. Fernández-Bolaños (Author), Magne O. Sydnes (Author), Emil Lindbäck (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters were investigated for the inhibition of acetylcholinesterase. Two of the tacrine...