Effect of multiple neonatal sevoflurane exposures on hippocampal apolipoprotein E levels and learning and memory abilities

• Main Authors: Junli Jiang (Author), Chunchun Tang (Author), Juanjuan Ren (Author), Chao Zhang (Author), Liang Dong (Author), Zhaoqiong Zhu (Author)
• Format: Book
• Published: Elsevier, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Sevoflurane anesthesia is widely used in pediatric patients. In this study, we investigated whether early multiple exposures to sevoflurane induced cognitive dysfunction by altering the hippocampal expression of ApoE later in development. Methods: Sprague-Dawley rats were exposed to 2.6%...